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                        Benecel? products are high purity, water-souble, nonionic cellulose ethers.  Benecel? hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications.  HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.  The Benecel? family of pharmaceutical products, including Benecel? XR and XRF HPMC, custom grades of Benecel? HPMC, and Benecel? DC HPMC, provides a full portfolio to support the controlled release of a broad range of APIs and manufacturing processes.

                        Benecel? XR and XRF HPMC grades:

                        Benecel? XR and XRF are high-viscosity grades of HPMC with optimized polymer structure and particle morphology for use in matrix controlled-release systems.

                        Features and Benefits:

                        - Optimized polymer structure and particle morphology
                        - Consistent particle size distribution and bulk density
                        - Enhanced compactibility at high tableting speeds vs standard grades
                        - Fine particle size grades available (XRF)

                         BenecelXRXRFGrades.JPG

                        Custom Grades of HPMC for Controlled Release:

                        Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending, however, can increase release-profile variability. Custom grades of Benecel? HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.

                        Features and Benefits:

                        - Increase predictability and reproducibility of drug release profiles
                        - Decrease research and development time needed to optimize blend ratio
                        - Decrease manufacturing time- no need to blend and manage multiple raw materials
                        - Opportunity to develop custom excipients

                         BenecelCustomGrades.JPG

                        Directly Compressible HPMC Grades:

                        Directly compressible (DC) grades enable the production of controlled-release formulations with the convenience of the most widely used tablet-binding mechanism. These Benecel? DC HPMC grades offer good powder flow, content uniformity, and compressibility, making them well suited for direct compression.

                        Features and Benefits:

                        - Improves product flow characteristics
                        - Reduces processing times
                        - Identical, stable dissolution profiles compared with “CR” grades
                        - Improves content uniformity
                        - Reduces production costs
                        - Retains tensile strength after double compaction (roller compaction) process

                         BenecelDCGrades.JPG

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